pyrazole derivatives targeting COXs

Non steroidal anti-inflammatory drugs (NSAIDS) represent one of the most common classes of medications used worldwide. It was recently reported that COX-1 inhibition alone causes little gastric ulcer formation. Therefore, we will focus in this proposal, on design of selective COX-1 inhibitors that could be used as potent analgesics with less gastric damage using the structure-based drug design and analogy approaches for the reported COX-1 inhibitors. Our preliminary studies were to determine the features required for a ligand to be COX-1 selective. The designed compounds were synthesized according to the reported synthetic methods. The compounds were tested in vitro to measure the selectivity index. The in vivo studies also were done for them.