أ.د. خالد رشاد أحمد عبد اللطيف المنصب الأكاديمي: أستاذ الكيمياء العضوية الصيدلية مناصب أخري: 1) رئيس قسم الكيمياء العضوية الصيدلية (سابقا) 2) وكيل الكلية (سابقا) 3) عميد الكلية (سايقا) الأتصال: khaledelshemy1@yahoo.com الدرجات العلمية: 2005 دكتوراة في الكيمياء العضوية الصيدلية كلية الصيدلة جامعة القاهرة مصر 2001 ماجيستير في الكيمياء العضوية الصيدلية كلية الصيدلة جامعة القاهرة مصر 1994 بكالوريوس في العلوم الصيدلية كلية الصيدلة جامعة القاهرة مصر عنوان رسالة الماجستير: تشييد ادوية لعلاج البلهارسيا Antibilharzial drugs عنوان رسالة الدكتوراه: تخليق بعض مركبات بيريدوثيوبيرانويندازول الجديدة كعوامل محتملة لإدخال الحمض النووي في العلاج الكيميائي للسرطان Synthesis of certain novel pyridothiopyranoindazoles as potential DNA intercalators in cancer chemotherapy المهام التدريسية: Pharmaceutical Organic Chemistry 1 Pharmaceutical Organic Chemistry 2 أبحاث مختارة: 1. Vicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme‐1/cyclooxygenase 2 inhibitors: Design, synthesis, anti‐hypertensive, anti‐fibrotic, and anti‐inflammatory Wael A. A. Fadaly, Yaseen A. M. M. Elshaier, Aly, F .E M, El‐Bahrawy, A H, .Abdellatif, K .R. A., Mohamed T. M. Nemr, Drug Development Research,2024;85:e22217. https://doi.org/10.1002/ddr.22217 2. New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study. Wael A. A. Fadaly, Mohamed T. M. Nemr, Taha H. Zidan, Fatma E. A.Mohamed, Marwa M. Abdelhakeem, Nour N. Abu Jayab, Hany A. Omar &Abdellatif, K .R. A., Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, VOL. 38, NO. 1, 229046. https://doi.org/10.1080/14756366.2023.2290461 3. Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments. Elbadawi, M. M.; Khodair, A. I.; Awad, M. K.; Kassab, S. E.; Elsaady M. T.; Abdellatif, K .R. A., Journal of Molecular Structure, 2022, 1249, 131574. https://doi.org/10.1016/j.molstruc.2021.131574 4. Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: anti-inflammatory activity, histopatholgical profile and in-silico studies. Abdellatif, K .R. A., Abdelall, E.K.A., Elshemy, H. A., Elnahas, E., Amin, D. M. E. Journal of Molecular Structure, 2021, 1240, 130554. https://doi.org/10.1016/j.molstruc.2021.130554 5. Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies. Abdellatif, K .R. A., Abdelall, Elshemy, H. A. H., ...Hassanein, E.H.M., Kahk, N.M., Bioorganic chemistry, 2021, 114, 105122. https://doi.org/10.1016/j.bioorg.2021.105122 6. Design, synthesis, biological assessment and: In silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors. Badawy, M.A.S., Abdelall, E.K.A., El-Nahass, E.-S., Abdellatif, K. R. A., Abdel-Rahman, H.M., RSC Advances, 2021, 11(44), 27659–27673. DOI https://doi.org/10.1039/D1RA04756F 7. HCV NS5B RdRp mutations and their effects on ligand binding affinity. Emam, A., Abdellatif, K .R. A., Amin, N.H., Elokely, K.M, International Journal of Modelling and Simulation, 2021, 00, 00000. https://doi.org/10.1080/02286203.2021.1923953 8. New indomethacin analogs as selective COX-2 inhibitors: Synthesis, COX-1/2 inhibitory activity, anti-inflammatory, ulcerogenicity, histopathological, and docking studies. Abdellatif, K .R. A., Abdelall, E.K.A., Elshemy, H. A. A., El-Nahass, E.-S.c, Abdel-Fattah, M. M. d, Abdelgawad, Y. Y. M.. Archiv Der Pharmazie, 2021, 11(44), 27659–27673. https://doi.org/10.1002/ardp.202000328 9. Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment. Abdellatif, K .R. A., Bakr, R. B., Medicinal Chemistry Research, 2021, 30(1), 31–49. DOI 10.1007/s00044-020-02656-8. 10. Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: anti-inflammatory activity, histopatholgical profile and in-silico studies. Abdellatif, K .R. A., Abdelall, E.K.A., Labib, M.B., Fadaly, W.A.A., Zidan, T.H.. Bioorganic Chemistry, 2020, 00, 00000. https://doi.org/10.1016/j.bioorg.2020.104418 11. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Abdellatif, K .R. A., Belal, A., El-Saadi, M. T., Amin, N. H., Said, E. G., Hemeda, L. R., Bioorganic Chemistry, 2020, 101, 103976. https://doi.org/10.1016/j.bioorg.2019.103540. 12. Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: Multi-target compounds with dual antimicrobial and anti-inflammatory activities. Shaker, A. M. M., Abdelall, E. K. A., Abdellatif, K. R. A., Abdel-Rahman, H. M., BMC Chemistry, 2020, 14(1), 23. 13. New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies. Abdellatif, K .R. A., Abdelall, E. K. A., Lamie, P. F., Labib, M. B., El-Nahaas, E., Abdelhakeem, M. M., Bioorganic Chemistry, 2020, 95, 103540. https://doi.org/10.1016/j.bioorg.2019.103540 14. New 1,2,4-Triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies. Fadaly, W. A. A., Elshaier, Y. A. M. M., Hassanein, E. H. M., Abdellatif, K .R. A., Bioorganic Chemistry, 2020, 98,103752. https://doi.org/10.1016/j.bioorg.2020.103752. 15. Treatment of breast cancer with engineered novel pH-sensitive triaryl-(Z)-olefin niosomes containing hydrogel: an in vitro and in vivo study. Salem, H.F., Kharshoum, R.M., Gamal F, A., Abo El-Ela, F.I., Abdellatif, K.R.A. Journal of Liposome Research, 2020, 30(2), pp. 126-135. https://doi.org/10.1080/08982104.2019.1601213. 16. New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents. Abdellatif, K .R. A., El-Saadi, M. T., Elzayat, S. G., Amin, N. Future Medicinal Chemistry, 2019, 11(15), 1870-1887. https://doi.org/10.4155/fmc-2018-0548. 17. Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities. Abdellatif, K .R. A., Fadaly, W.A.A., Mostafa, Y. A., Zaher, D. M., Omar, H. A. Bioorganic Chemistry, 2019, 91, 103132. https://doi.org/10.1016/j.bioorg.2019.103132. 18. Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors. Abdellatif, K .R. A., Abdelall, E.K.A., Labib, M.B., Fadaly, W.A.A., Zidan, T.H.. Bioorganic Chemistry, 2019, 90, 103029. https://doi.org/10.1016/j.bioorg.2019.103029. 19. Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors. Abdellatif, K .R. A., Fadaly, W. A. A., Kamel, G. M. Elshaier, Y. A. M. M., El-Maged, M. A. Bioorganic Chemistry, 2019, 82, 86-99. https://doi.org/10.1016/j.bioorg.2018.09.034. 20. Anti-inflammatory indomethacin analogs endowed with preferential COX-2 inhibitory activity. Amin, N. H., El-Saadi M. T., Hefny, A. A., Amin, N. H., Elshemy, H. A. A., Abdellatif, K. R. A. Future Medicinal Chemistry, 2018, 10 (21), 2521–2535. 21. Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities. Abdelatef, S. A., El-Saadi, M. T., Amin, N. H., Abdelazeem, A. H., Abdellatif, K. R. A. European Journal of Medicinal Chemistry, 2018, 150, 567-578. https://doi.org/10.1016/j.ejmech.2018.03.001. 22. Non-acidic 1,3,4-trisubstituted-pyrazole derivatives as lonazolac analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile. Abdellatif, K .R. A., Fadaly, W. A. A., Elshaier, Y. A. M. M., Kamel, G. M. Bioorganic Chemistry, 2018, 77, 568-578. 23. Novel 4-methylsulfonylphenyl derivatives as NSAIDS with preferential COX-2 inhibition. Abdelatef, S. A., El-Saadi, M. T., Amin, N. H., Abdelazeem, A. H., Abdellatif, K. R. A. Journal of Applied Pharmaceutical Science, 2018, 8(1), 009-016. 24. New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds. Abdellatif, K. R. A.; Bakr, R. B. Bioorganic Chemistry, 2018, 78, 341-357. DOI: https://doi.org/10.1016/j.bioorg.2018.03.032. 25. Novel 4-methylsulfonylphenyl derivatives as NSAIDS with preferential COX-2 inhibition. Amin, N. H.; Mohammed A. A.; Abdellatif, K. R. A. Future Medicinal Chemistry, 2018, 10 (1), 53-70, DOI: 10.4155/fmc-2017-0153. 26. Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer. Salem, H. F.; Kharshoum, R. M.; Abo El-Ela, F. I.; Gamal, A. F.; Abdellatif, K. R. A. Drug Delivery and Translational Research, 2018, https://doi.org/10.1007/s13346-018-0499-3. 27. 2,4-Disubstituted Phenylhydrazonopyrazolone and Isoxazolone Derivatives as Antibacterial Agents: Synthesis, Preliminary Biological Evaluation and Docking Studies. Oraby, A. K.; Abdellatif, K. R. A.; Abdelgawad, M. A.; Attia, K. M.; Georghiou, P. E.; Dawe, L. N. Chemistry Select, 2018, 3 (11), 3295-3301. DOI: 10.1002/slct.201800174. 28. Design, Synthesis and Cytotoxicity Evaluation of New 3, 5-Disubstituted-2-Thioxoimidazolidinones. Abdellatif, K. R. A.; Elbadawi, M. M.; Elsaady M. T.; Abd El-Hafeeze, A. A.; Fujimurae, T.; Kawamotoe S.; Khodair, A. I. Anti-Cancer Agents in Medicinal Chemistry, 2018, 18 (4), 573–582. DOI:10.2174/1871520618666171129213838. 29. Design, synthesis, and biological evaluation of 2-(4-(methylsulfonyl)phenyl) indole derivatives with promising COX-2 inhibitory activity. Ahmed M. M. Shaker, A. M. M., Abdelall, E. K. A., Abdellatif, K. R. A., Abdel-Rahman, H. M. Journal of Applied Pharmaceutical Science, 2018, 8 (11): 1-8. 30. Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl4-(substituted-methoxy)pyrazolo[3,4-d]pyrimidine Derivatives. Rania B. B.; Mehney A. B.; Abdellatif, K. R. A. Anti-Cancer Agents in Medicinal Chemistry, 2017, 17 (10), 1389-1400. 31. Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX-2 Inhibitors. Abdellatif, K. R. A. Abdelgawad, M. A.; Madlen, B. L.; Zidan, T. A. Archiv Der Pharmazie, 2017, 350, e1600386 32. Design, synthesis, molecular docking and cytotoxicity evaluation of some novel 5-arylidene-3-(substituted phenyl)-2-(p-tolylamino)-4-imidazolones. Ahmed I. KhodairA.; Elbadawi M. M.; , Elsaady M. T.; Abdellatif K. R. A. Journal of Applied Pharmaceutical Science, 2017, 7 (9), 58-68. 33. Nitric Oxide-NSAIDs Donor Prodrugs as Hybrid Safe Anti-inflammatory Agents. Abdellatif, K. R. A.; Abdelall, E. K. A.; Bakr, R. B. 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Design, synthesis and biological evaluation of new 4-(4-substitutedanilino)quinoline derivatives as anticancer agents. Abdellatif, K. R. A.; Abdelall, E. K. A.; Abdelgawad, M. A.; Amin; D. A. E.; Omar; H. M. Medicinal Chemistry Research, 2017, 26, 929–939, DOI: 10.1007/s00044-017-1798-9 38. Synthesis, Anti-inflammatory and Molecular Docking Study of Schiff Bases Containing Methanesulphonyl Pharmacophore. Abdellatif, K. R. A. Elsaady, M. T.; Abdel-Aziz S. A.; Abu Sabah, A. H. A. Letters in Drug Design and Discovery, 2017, 14, 930-937, DOI: 10.2174/15701808146661612141637 59. 39. Design, Synthesis, Antioxidant and Anticancer Activity of New Coumarin Derivatives Linked with Thiazole, Isoxazole or Pyrazole Moiety. Abdellatif, K. R. A.; Abdelgawad, M. A.; Elshemy, H. A. H.; Kahk, N. M. Letters in Drug Design and Discovery, 2017, 14, 773-781, DOI: 10.2174/15701808136661610261537 43. 40. Synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile. Alsayed, S. S. R.; Elshemy, H. A. H.; Abdelgawad, M. A.; Abdel-Latif, M. S.; Abdellatif, K. R. A. Bioorganic Chemistry, 2017, 70, 173-183, DOI: 10.1016/j.bioorg.2016.12.008. 41. Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,5-diarylpyrazole derivatives. Abdellatif, K. R. A. Fadally, W.; Aly, W. A. M.; Kamel, G. Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 54-60, DOI: 10.1080/14756366.2016.1201815 42. Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline derivatives possessing methanesulphonyl pharmacophore. Abdellatif, K. R. A. Fadally, W. A.; Azouz, A. A. Archiv Der Pharmazie, 2016, 349, 801–807, DOI 10.1002/ardp.201600145. 43. Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of 1-phenylpyrazolo[3,4-d]pyrimidine derivatives. Bakr, R. B.; Azouz, A. A.; Abdellatif, K. R. A. Journal of enzyme inhibition and medicinal chemistry, 2016, 31 (S2), 6-12, http://dx.doi.org/10.1080/14756366.2016.1186018 44. Synthesis and Antimicrobial Activities of a Series of Disubstitutedarylazo-Barbituric- and Thiobarbituric Acid Derivatives. Oraby, A. K.; Abdellatif, K. R. A.; Abdelgawad, M. A.; Attia, K. M.; Georghiou, P. E. International Journal of Pharmaceutical Chemistry, 2016, 6 (4), 100-106. 45. Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore. Abdellatif, K. R. A.; Mohammed T. Elsaady, M. T.; Salah A. Abdel-Aziz, S. A.; Abusabaa, A. H. A. 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Bioorganic & Medicinal Chemistry Letters 2016, 26, 406-412, https://doi.org/10.1016/j.bmcl.2015.11.105 49. Design and synthesis of certain novel bicoumarin derivatives asanticancer agents. Abdellatif, K. R. A.; Abdelgawad, M. A.; Elshemy, H. A. H.; Kahk, N. M. Der Pharma Chemica, 2016, 8(3), 13-19. 50. Synthesis of some benzoxazole derivatives and their anti-inflammatory evaluation. Abdellatif, K. R. A.; Amin, N. H.; Mohammed, A. A. Journal of Chemical and Pharmaceutical Research, 2016, 8(4), 1253-1261. 51. Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents. Abdellatif, K. R. A.; Phoebe F. Lamie, and Hany A. Omar. Journal of enzyme inhibition and medicinal chemistry, 2016, 31 (2), 318-324, . DOI: 10.3109/14756366.2015.1022174 52. Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors. Abdellatif, K. R. A.; Abdelgawad, M. A.; Madlen, B. L.; Zidan, T. H. Bioorganic & Medicinal Chemistry Letters, 2015, 25 (24), 5787-5791, https://doi.org/10.1016/j.bmcl.2015.10.047 53. Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline or pyridine ring. Abdellatif, K. R. A.; Abdelall, E. K.; Fadally, W.; Kamel, G. Medicinal Chemistry Research, 2015, 24, 2632-2644, DOI 10.1007/s00044-015-1327-7 54. 1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoro-methylphenyl)-1H-2-pyrazolines/ pyrazoles as potential anti-inflammatory agents. Abdellatif, K. R. A.; Elshemy, H. A. H.; Azouz, A. A. Bioorganic Chemistry 2015, 63, 13-23, https://dx.doi.org/10.1016/j.bioorg.2015.09.0020045-2068 55. Synthesis and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing an aminosulphonyl pharmacophore. Abdellatif, K. R. A.; Abdelgawad, M. A.; Elshemy, H. A. H.; Alsayed, S. S. R.; Kamel, G. Archives of Pharmacal Research, 2015, 38, 1932-1942, DOI 10.1007/s12272-015-0606-7 56. Design and synthesis of certain novel arylidene thiazolidinone derivatives as anticancer agents. Abdellatif, K. R. A.; Abdelall, E. K. A.; Abdelgawad, M. A.; Abdelhakeem, M. M.; Omar, H. A. Der Pharma Chemica, 2015, 7(8), 149-161. 57. Synthesis, characterization and biological evaluation of novel 4--fluoro-2--hydroxychalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. Abdellatif, K. R. A.; Heba A. H. Elshemy, Samir A. Salama, and Hany A. Omar. Journal of enzyme inhibition and medicinal chemistry 2015, 30 (3), 484-491, DOI: 10.3109/14756366.2014.949255 58. Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: A search for novel nitric oxide donor anti-inflammatory agents. Abdellatif, K. R. A.; Moawad, A.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2014, 24, 5015-5021. 59. Synthesis and anticancer activity of some new pyrazolo[3,4-d]pyrimidin-4-one derivatives. Abdellatif, K. R. A.; Abdelall, E. K. A.; Abdelgawad, M. A.; Ahmed, R. A.; Bakr, R. B. Molecules 2014, 19, 3297-3309. doi:10.3390/molecules19033297. 60. Design, synthesis and anticancer screening of novel pyrazole derivatives linking to benzimidazole, benzoxazole and benzothiazole. Abdelgawad, M. A.; Abdellatif, K. R. A.; Ahmed, O. M. Medicinal Chemistry an Open Access 2014, S1, 1-7. 61. Design, synthesis and pharmaological evaluation of novel pyrrolizine derivatives as potential anticancer agents. Gouda, A. M; Abdelazeem, A. H.; Arafa, E. A.; Abdellatif, K. R. A. Bioorganic Chemistry 2014, 53, 1-7, https://doi.org/10.1016/j.bioorg.2014.01.001 62. Synthesis, docking study and antitumor evaluation of certain newly synthesized pyrazolo[3,4-d]pyrimidine derivative. Abdellatif, K. R. A.; Abdelall, E. K. A.; Abdelgawad, M. A.; Ahmed, R. A.; Bakr, R. B. Organic Chemistry An Indian Journal 2014, 10(3),157-167. 63. Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues. Abdellatif, K. R. A.; Belal, A.; Omar, H. M. Bioorganic & Medicinal Chemistry Letters 2013, 23, 4960-4963, https://doi.org/10.1016/j.bmcl.2013.06.056 64. Synthesis of rofecoxib analogs of expected antiinflamatory activity. Abdellatif, K. R. A.; Abdelgawad, M. A.; Helmy, N. A. Der Pharmacia Lettre 2013, 5(2), 228-237. 65. Synthesis of novel subistituted 4H-chromenes and their antioxidant screening. Abdelgawad, M. A.; Elshemy, H. A. H.; Abdellatif, K. R. A.; Omar, H. M. Journal of Chemical and Pharmaceutical research 2013, 5(1), 387-394. 66. Synthesis and antimicrobial activity of novel 2-subistituted-1H-benzimidazole derivatives. Abdellatif, K. R. A.; Elshemy, H. A. H.; El-Badry, O. M.; Ragab, H. M.; El-Enany, M. M. Organic Chemistry An Indian Journal 2013, 9(3). 67. Ethanesulfohydroxamic Acid Ester Prodrugs of Non-steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis, Nitric oxide and Nitroxyl Release, Cyclooxygenase Inhibition, Anti-inflammatory and Ulcerogenicity Index Studies. Huang, Z; Velázquez, C. A.; Abdellatif, K. R. A.; Chowdhury, M. A. ; Reisz, J.; DuMong, J.; S. Bruce, S. B.; Knaus, E. E. Journal of Medicinal Chemistry 2011, 54, 1356-1364, dx.doi.org/10.1021/jm101403g 68. A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: Synthesis, biological evaluation and nitric oxide release studies. Abdellatif, K. R. A.; Huang, Z; Chowdhury, M. A ; Kaufman, S.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2011, 21, 3951-3956, doi:10.1016/j.bmcl.2011.05.017 69. Synthesis of phenylacetic acid regioisomers possessing a N-substituted-1,2-dihydropyrid-2-one pharmacophore: Evaluation as inhibitors of cyclooxygenases and 5-lipoxygenase. Ya, G.; Chowdhury, M. A ; Huang, Z; Abdellatif, K. R. A.; Knaus, E. E. Canadian Journal of Chemistry 2011, 89, 617-622, doi:10.1139/V11-048 70. Triaryl (Z)-olefins suitable for radiolabelling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors. Abdellatif, K. R. A.; Velázquez, C. A.; Huang, Z;; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2011, 21, 1195-1198, doi:10.1016/j.bmcl.2010.12.091 71. Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: A search for novel cyclooxygenase and lipoxygenase inhibitors. Chowdhury, M. A.; Huang, Z.; Abdellatif, K. R. A.; Dong, Y.; Ya, G.; Velázquez, C. A.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2010, 20, 5776-5780, doi:10.1016/j.bmcl.2010.07.132 72. Comparison between NO-ASA and NONO-ASA as safe anti inflammatory, analgesic, antipyretic, anti-oxidant prodrugs. Chattopadhyay, M.; Velazquez, C. A.; Pruski, A.; Nia, K. V.; Abdellatif, K. R. A.; Keefer, L. K.; Khosrow K. Journal of Pharmacology and Experimental Therapeutics, 2010, 335, 443-450, doi:10.1124/jpet.110.171017 73. Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmaco-phore: Synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies. Huang, Z.; Velázquez, C. A.; Abdellatif, K. R. A.; Chowdhury, M. A.; Reisz, J.; DuMong, J.; S. Bruce, S. B.; Knaus, E. E. Journal of Organic and Biomolecular Chemistry 2010, 8, 4124-4130, DOI: 10.1039/c005066k 74. Triaryl (Z)-olefins suitable for radiolabelling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease. Abdellatif, K. R. A.; Velázquez, C. A.; Huang, Z; Chowdhury, M. A.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2010, 20, 5245-5250, doi:10.1016/j.bmcl.2010.06.155 75. Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolated nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies. Abdellatif, K. R. A.; Chowdhury, M. A.; Velázquez, C. A.; Huang, Z; Dong, Y.; Das, D.; Ya, G.; Suresh, M. R.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2010, 20, 4544-4549, doi:10.1016/j.bmcl.2010.06.022 76. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase. Ya, G.; Rao, P. N. P.; Chowdhury, M. A.; Abdellatif, K. R. A.; Dong, Y.; Das, D.; Velázquez, C. A.; Suresh, M. R.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2010, 20, 2168-2173, doi:10.1016/j.bmcl.2010.02.040 77. Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies. Chowdhury, M. A.; Abdellatif, K. R. A.; Dong, Y.; Ya, G.; Huang, Z.; RAhman, M.; Das, D.; Velázquez, C. A.; Suresh, M. R.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2010, 20, 1324-1329, doi:10.1016/j.bmcl.2010.01.014 78. Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2- dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Ya, G.; Chowdhury, M. A.; Abdellatif, K. R. A.; Dong, Y.; Das, D.; Rao, P. N. P.; Velázquez, C. A.; Suresh, M. R.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2010, 20, 896-902, doi:10.1016/j.bmcl.2009.12.073 79. Synthesis and antibacterial activity of novel quinoxalinone derivatives. Shaaban, M. A.; Khalil, M. O.; Abdellatif, K. R. A.; Lamie, P. F. Journal of Chemical Research, 2009, September, 574-578. 80. Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulphonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Chowdhury, M. A.; Abdellatif, K. R. A.; Dong, Y.; Das, D.; Velázquez, C. A.; Ya, G.; Suresh, M. R.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2009, 19, 6855-6861, doi:10.1016/j.bmcl.2009.10.083 81. Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl -1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies. Abdellatif, K. R. A.; Chowdhury, M. A.; Dong, Y.; Das, D.; Yu, G.; Velázquez, C. 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Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one)pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Chowdhury, M. A.; Abdellatif, K. R. A.; Dong, Y.; Rahman, M.; Das, D.; Suresh, M. R.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2009, 19, 584-588, doi:10.1016/j.bmcl.2008.12.066 85. Synthesis of new 1-(2-, 3- or 4-methanesulfonylphenyl)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A search for novel cyclooxygenase and lipoxygenase inhibitors. Chowdhury, M. A.; Chen, H.; Abdellatif, K. R. A.; Dong, Y.; Petruk, K. C.; Knaus, E. E. Journal of Heterocyclic Chemistry, 2009, 46, 58-61, DOI 10.1002/jhet 86. Synthesis of celecoxib analogs that possess a N-hydroxypyridin-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cycloxygenases and 5-lipoxygenase with anti-inflammatory activity. 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Synthesis of new 1-[4-methane(amino)sulfonylphenyl)]-5-[4-(aminophenyl)]-3-trifluoromethyl-1H-pyrazoles. Abdellatif, K. R. A.; Chowdhury, M. A.; Knaus, E. E. Journal of Heterocyclic Chemistry 2008, 45, 1707-1710, https://doi.org/10.1002/jhet.5570450623 90. Synthesis and biological evaluation of 1-(4-benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A novel class of 5-lipoxygenase inhibitors. Chowdhury, M. A.; Chen, H.; Abdellatif, K. R. A.; Dong, Y.; Petruk, K. C.; Knaus, E. E. Bioorganic & Medicinal Chemistry Letters 2008, 18, 4195-4198, doi:10.1016/j.bmcl.2008.05.071 91. Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: Synthesis, nitric oxide release studies and anti-inflammatory activities. Abdellatif, K. R. A.; Chowdhury, M. A.; Dong, Y.; Knaus, E. E. Bioorganic &Medicinal Chemistry 2008, 16, 6528-6534, doi:10.1016/j.bmc.2008.05.028 92. Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonyl-phenyl)acrylic acids: Synthesis, cyclooxygenase inhibition and nitric oxide release studies. Abdellatif, K. R. A.; Chowdhury, M. A.; Dong, Y.; Chen Q. -H.; Knaus, E. E. Bioorganic and Medicinal Chemistry 2008, 16, 3302-3308, doi:10.1016/j.bmc.2007.12.006 93. Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Chowdhury, M. A.; Dong, Y.; Chen, Q. -H.; Abdellatif, K. R. A.; Knaus, E. E. Bioorganic & Medicinal Chemistry, 2008, 16, 1948-1956, doi:10.1016/j.bmc.2007.11.003 94. Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: Design, synthesis, cyclooxygenase inhibition and nitric oxide release studies. Abdellatif, K. R. A.; Dong, Y.; Chen, Q. H.; Chowdhury, M. A. Knaus, E. E. 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